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![癌症免疫疗法新技术——溶瘤假病毒]()
癌症免疫疗法新技术——溶瘤假病毒
自免疫检查点抑制剂首次成功应用于黑色素瘤患者以来，抗癌免疫疗法已经变得多样化，并联合放疗、化疗成为多种恶性肿瘤适应症的治疗标准。目前批准的免疫疗法包括针对免疫检查点和肿瘤相关抗原的单克隆抗体、免疫刺激细胞因子、CAR-T细胞、基于树突状细胞的癌症疫苗，以及局部应用的溶瘤病毒疗法。越来越多的临床前证据支持这样一种观点：不仅局部病毒疗法，其他物理或化学溶瘤的非病毒疗法（激光、微波、射频或光热疗法；高强
2020-08-10
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![Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer – translational results from the AIO-PK0104 Phase 3 study]()
Bacterial lipopolysaccharide as negative predictor of gemcitabine efficacy in advanced pancreatic cancer – translational results from the AIO-PK0104 Phase 3 study
AbstractBackgroundGram-negative bacteria mediated gemcitabine resistance in pre-clinical models. We determined if intratumoural lipopolysaccharide (LPS) detection by immunohistochemistry is associated
2020-08-10
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![Nature子刊：PD-1抗体对谁有效？验血就能预知答案！]()
Nature子刊：PD-1抗体对谁有效？验血就能预知答案！
免疫疗法是治疗晚期癌症的一种选择，尽管其已被证明可以缩小肿瘤并延长其他治疗失败患者的生存期，但是大约只有20%–30%的患者可从中受益。目前，临床医生还不能预判这部分病人是谁。检测血液中肿瘤碎片水平变化的测试可能是一种简单、无创和快速预测谁将受益于免疫治疗的方法。了解这一点是至关重要的，因为免疫疗法在一小部分患者中可能会产生严重的副作用，而知道是否要开始或继续治疗将有助于患者权衡不同的治疗方案。由
2020-08-03
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![Scientists make precise gene edits to mitochondrial DNA for first time]()
Scientists make precise gene edits to mitochondrial DNA for first time
Weird enzyme enables researchers to study — and potentially treat — deadly diseases.
2020-07-28
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![Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma]()
Longitudinal monitoring of circulating tumour DNA improves prognostication and relapse detection in gastroesophageal adenocarcinoma
AbstractBackgroundGastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as an emerging biomarker.MethodsFort
2020-07-28
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![Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters]()
Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters
AbstractWe developed a functional lineage tracing tool termed CaTCH (CRISPRa tracing of clones in heterogeneous cell populations). CaTCH combines precise clonal tracing of millions of cells with the a
2020-07-28
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![Contact Dermatitis: An Overview]()
Contact Dermatitis: An Overview
Contact Dermatitis: An OverviewImage courtesy of Wikimedia Commons | Lauren Jill Ahrold.Justin Finch, MD; Sarah Mattessich | July 23, 2020 | Contributor InformationAs the body's primary barri
2020-07-24
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![Engineering synthetic breath biomarkers for respiratory disease]()
Engineering synthetic breath biomarkers for respiratory disease
AbstractHuman breath contains many volatile metabolites. However, few breath tests are currently used in the clinic to monitor disease due to bottlenecks in biomarker identification. Here we engineere
2020-07-20
